2022, Vol. 4, Issue 2, Part D

Author(s): S Raja Sekhara Reddy and Dr. Anuj Kumar Sharma

Abstract: Phytosomes are complex structures formed by the molecular complexation of plant-derived bioactive compounds with phospholipids, primarily phosphatidylcholine. This interaction leads to the formation of a unique complex wherein the phytoconstituents are embedded within the phospholipid bilayer. The resulting phytosomes exhibit improved solubility, stability, and absorption characteristics compared to free phytochemicals. The properties of phytosomes, including particle size, morphology, zeta potential, and encapsulation efficiency, play a crucial role in determining their pharmaceutical attributes. Various analytical techniques such as dynamic light scattering, transmission electron microscopy, Fourier-transform infrared spectroscopy, and differential scanning calorimetry are employed for the characterization of phytosomes. Formulation strategies for phytosomes involve the selection of appropriate phospholipids, optimization of the drug-to-lipid ratio, and incorporation of excipients to enhance stability and efficacy. Phytosomes can be formulated into various dosage forms including oral tablets, capsules, creams, and gels, catering to diverse therapeutic applications. In conclusion, phytosomes represent a promising drug delivery system for enhancing the bioavailability and therapeutic efficacy of plant-derived bioactive compounds. Further research in the characterization, formulation, and evaluation of phytosomes holds significant potential for the development of novel phytopharmaceutical formulations with enhanced therapeutic benefits.

Pages: 229-234 | Views: 126 | Downloads: 94

Download Full Article: Click Here